Han, Huijong, Ph.D.

Personal Information vCard

• E-mail : hjhan@ku.edu
• Homepage : www.zannavi.com/huijong (this page)
• Spouse: Son, Sang-Kil

Education

Aug. 2003 ~ Sep. 2008	Ph. D. in Medicinal Chemistry, University of Kansas, United States (Research Assistantship) Thesis: The Application of X-ray Crystallography Towards the Design of Novel Inhibitors of MurA and CDK2, Ph.D. Thesis, University of Kansas (2008) [BibTeX][pdf][abstract] M. S. in Medicinal Chemistry, University of Kansas, United States Advisor: Prof. Ernst Schönbrunn Cloning, mutation, and purification of enolpyruvyl transferases and CDK2 High-throughput screening of enolpyruvyl transferases Inhibitor characterizations using enzymatic assays and structural studies Protein crystal screening with a crystallization robot, crystallization, X-ray data collection, and structure refinements New inhibitor design and identification by in silico screening
Mar. 1997 ~ Feb. 1999	M. S. in Chemistry, KAIST, South Korea (Full Scholarship from Government) Thesis: NMR study of catalytic DNA, M.S. Thesis, KAIST (1999) [BibTeX][abstract] Advisor: Prof. Byong-Seok Choi DNA synthesis and purification using DNA synthesizer and HPLC Structure determination of DNAs by NMR spectroscopy
Mar. 1993 ~ Feb. 1997	B. S. in Chemistry, KAIST, South Korea (Full Scholarship from Government for 4 years)

Working Experience

Oct. 2008 ~ present	H. Lee Moffitt Cancer Center & Research Institute, Post-Doctoral Fellow
Oct. 2007 ~ Sep. 2008	H. Lee Moffitt Cancer Center & Research Institute, Research Associate Characterization of enzymes by kinetic assays Crystallization, X-ray crystallographic data collection, and structure refinements New inhibitor design and identification by in silico screening and docking
Sep. 2000 ~ Mar. 2002	CrystalGenomics, Inc., Research Scientist Drug Discovery by molecular modelling Set up target-specific compound library Analysis of protein family structures
Apr. 1999 ~ Aug. 2000	Biotech Research Institute, LG Chem. Ltd., Research Scientist Drug Discovery using SAR by NMR spectroscopy Peptide structure determination using NMR spectroscopy

Publications

1. Joon-Hwa Lee, Jin-Young Park, Hi-Jung Han, and Byong-Seok Choi, Conformational Study of Decamer DNA Duplex d(ACGTATACGT)₂ by NMR Spectroscopy, J. Kor. Magn. Reson. Soc. 1, 63–70 (1997) [BibTeX][pdf][abstract]
2. Yun-Jeong Choi, Hui-Jong Han, Joon-Hwa Lee, Se-Won Suh, and Byong-Seok Choi, Synthesis and NMR Studies of the RNA-Cleaving DNA Enzyme, Bull. Korean Chem. Soc. 21, 955–956 (2000) [BibTeX][link][pdf]
3. Xiao Ming Yu, Huijong Han, and Brian S.J. Blagg, Synthesis of Mono- and Dihydroxylated Furanoses, Pyranoses, and an Oxepanose for the Preparation of Natural Product Analogue Libraries, J. Org. Chem. 70, 5599–5605 (2005) [BibTeX][link][pdf][abstract]
4. Todd Funke, Huijong Han, Martha L. Healy-Fried, Markus Fischer, and Ernst Schönbrunn, Molecular basis for the herbicide resistance of Roundup Ready crops, Proc. Natl. Acad. Sci. U. S. A. 103, 13010–13015 (2006) [BibTeX][link][pdf][abstract]
5. Todd Funke, Martha L. Healy-Fried, Huijong Han, David G. Alberg, Paul A. Bartlett, and Ernst Schönbrunn, Differential Inhibition of Class I and Class II 5-Enolpyruvylshikimate-3-phosphate Synthases by Tetrahedral Reaction Intermediate Analogues, Biochemistry 46, 13344–13351 (2007) [BibTeX][link][pdf][abstract]
6. Martha L. Healy-Fried, Todd Funke, Melanie A. Priestman, Huijong Han, and Ernst Schönbrunn, Structural Basis of Glyphosate Tolerance Resulting from Mutations of Pro¹⁰¹ in Escherichia coli 5-Enolpyruvylshikimate-3-phosphate Synthase, J. Biol. Chem. 282, 32949–32955 (2007) [BibTeX][link][pdf][abstract]
7. An Wang, Yuhong Zeng, Huijong Han, Saroja Weeratunga, Bailey N. Morgan, Pierre Moënne-Loccoz, Ernst Schönbrunn, and Mario Rivera, Biochemical and Structural Characterization of Pseudomonas aeruginosa Bfd and FPR: Ferredoxin NADP⁺ Reductase and not Ferredoxin is the Redox Partrner of Heme Oxygenase under Iron-Starvation Conditions, Biochemistry 46, 12198–12211 (2007) [BibTeX][link][pdf][abstract]
8. An Wang, Juan Carlos Rodríguez, Huijong Han, Ernst Schönbrunn, and Mario Rivera, X-ray Crystallographic and Solution State Nuclear Magnetic Resonance Spectroscopic Investigations of NADP⁺ Binding to Ferredoxin NADP Reductase from Pseudomonas aeruginosa, Biochemistry 47, 8080–8093 (2008) [BibTeX][link][pdf][abstract]
9. Todd Funke, Yan Yang, Huijong Han, Martha Healy-Fried, Sanne Olesen, Andreas Becker, and Ernst Schönbrunn, Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr⁹⁷ → Ile and Pro¹⁰¹ → Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli, J. Biol. Chem. 284, 9854–9860 (2009) [BibTeX][link][pdf][abstract]

Abstracts

1. Huijong Han, Joon-Hwa Lee, and Byong-Seok Choi, The Solution Structure of DNA Decamer Duplex Containing the Dewar Product of the Thymydylyl(3’–5’)thymidine by the NMR Spectroscopy and the Full Relaxation Matrix Refinement in XVIII International Conference on Magnetic Resonance in Biological Systems (Tokyo Metropolitan University, Tokyo, Japan, August 1998) [BibTeX]
2. Huijong Han, Joon-Hwa Lee, and Byong-Seok Choi, The Solution Structure of DNA Decamer Duplex Containing the Dewar Product of the Thymydylyl(3’–5’)thymidine by the NMR Spectroscopy and the Full Relaxation Matrix Refinement in Abstract of the 82nd Annual Meeting of the Korean Chemical Society (Oct. 23-24, 1998) [BibTeX]
3. Huijong Han, Todd Funke, Melanie Priestman, and Ernst Schönbrunn, Discovery and Evaluation of Novel MurA Inhibitors in Structure Based Drug Discovery (D6) (Keystone Symposia, Whistler, British Columbia, Canada, Apr. 4-9, 2006) [BibTeX]
4. Huijong Han, Todd Funke, Melanie Priestman, and Ernst Schönbrunn, Discovery of Novel MurA Inhibitors in The 6th Biennial GPEN Conference (University of Kansas, Lawrence, Kansas, Oct. 25-27, 2006) [BibTeX]
5. Huijong Han and Ernst Schönbrunn, Molecular Modes of Action of Novel CDK2 Inhibitors in The 45th Annual MIKI Meeting (University of Kansas, Lawrence, Kansas, Apr. 13-15, 2007) [oral presentation] [BibTeX]

Awards

• Goetsch Family Scholarship
• Full governmental scholarship for undergraduate and graduate students