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BibTeX file of [Srinivasan22] [show it without abstract]

@article{Srinivasan22,
    author={Vasundara Srinivasan and H{\'e}vila Brognaro and Prince R. Prabhu and Edmarcia Elisa de Souza and Sebastian G{\"u}nther and Patrick Y. A. Reinke and Thomas J. Lane and Helen Ginn and Huijong Han and Wiebke Ewert and Janina Sprenger and Faisal H. M. Koua and Sven Falke and Nadine Werner and Hina Andaleeb and Najeeb Ullah and Bruno Alves Franca and Mengying Wang and Ang{\'e}lica Luana C. Barra and Markus Perbandt and Martin Schwinzer and Christina Schmidt and Lea Brings and Kristina Lorenzen and Robin Schubert and Rafael Rahal Guaragna Machado and Erika Donizette Candido and Danielle Bruna Leal Oliveira and Edison Luiz Durigon and Stephan Niebling and Angelica Struve Garcia and Oleksandr Yefanov and Julia Lieske and Luca Gelisio and Martin Domaracky and Philipp Middendorf and Michael Groessler and Fabian Trost and Marina Galchenkova and Aida Rahmani Mashhour and Sofiane Saouane and Johanna Hakanp{\"a}{\"a} and Markus Wolf and Maria Garcia Alai and Dusan Turk and Arwen R. Pearson and Henry N. Chapman and Winfried Hinrichs and Carsten Wrenger and Alke Meents and Christian Betzel},
    title={Antiviral activity of natural phenolic compounds in complex at an allosteric site of {SARS-CoV-2} papain-like protease},
    journal={Commun. Biol.},
    volume={5},
    pages={805},
    year={2022},
    keywords={corona; covid; XBI; European XFEL;},
    url={https://doi.org/10.1038/s42003-022-03737-7},
    doi={10.1038/s42003-022-03737-7},
    abstract={SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the additional and vital function of removing ubiquitin and ISG15 (Interferon-stimulated gene 15) from host-cell proteins to support coronaviruses in evading the host¡¯s innate immune responses. We identified three phenolic compounds bound to PLpro, preventing essential molecular interactions to ISG15 by screening a natural compound library. The compounds identified by X-ray screening and complexed to PLpro demonstrate clear inhibition of PLpro in a deISGylation activity assay. Two compounds exhibit distinct antiviral activity in Vero cell line assays and one inhibited a cytopathic effect in non-cytotoxic concentration ranges. In the context of increasing PLpro mutations in the evolving new variants of SARS-CoV-2, the natural compounds we identified may also reinstate the antiviral immune response processes of the host that are down-regulated in COVID-19 infections.
    } }



Vasundara Srinivasan, Hévila Brognaro, Prince R. Prabhu, Edmarcia Elisa de Souza, Sebastian Günther, Patrick Y.A. Reinke, Thomas J. Lane, Helen Ginn, Huijong Han, Wiebke Ewert, Janina Sprenger, Faisal H.M. Koua, Sven Falke, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Bruno Alves Franca, Mengying Wang, Angélica Luana C. Barra, Markus Perbandt, Martin Schwinzer, Christina Schmidt, Lea Brings, Kristina Lorenzen, Robin Schubert, Rafael Rahal Guaragna Machado, Erika Donizette Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Stephan Niebling, Angelica Struve Garcia, Oleksandr Yefanov, Julia Lieske, Luca Gelisio, Martin Domaracky, Philipp Middendorf, Michael Groessler, Fabian Trost, Marina Galchenkova, Aida Rahmani Mashhour, Sofiane Saouane, Johanna Hakanpää, Markus Wolf, Maria Garcia Alai, Dusan Turk, Arwen R. Pearson, Henry N. Chapman, Winfried Hinrichs, Carsten Wrenger, Alke Meents, and Christian Betzel, Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease, Commun. Biol. 5, 805 (2022) [pdf][pdf][abstract][abstract][link]doi:10.1038/s42003-022-03737-7


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