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BibTeX file of [Jacot16] [show it without abstract] @article{Jacot16, author={Damien Jacot and Nicol{\`o} Tosetti and Isa Pires and Jessica Stock and Arnault Graindorge and Yu-Fu Hung and Huijong Han and Rita Tewari and Inari Kursula and Dominique Soldati-Favre}, title={An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion}, journal={Cell Host Microbe}, volume={20}, pages={731--743}, year={2016}, keywords={gliding motility; invasion and egress; glideosome; actin dynamic; apicomplexa; plasmodium; toxoplasma; lysine methyltransferase; phosphatidic acid; microneme;}, url={https://doi.org/10.1016/j.chom.2016.10.020}, doi={10.1016/j.chom.2016.10.020}, abstract={Apicomplexa exhibit a unique form of substrate-dependent gliding motility central for host cell invasion and parasite dissemination. Gliding is powered by rearward translocation of apically secreted transmembrane adhesins via their interaction with the parasite actomyosin system. We report a conserved armadillo and pleckstrin homology (PH) domain-containing protein, termed glideosome-associated connector (GAC), that mediates apicomplexan gliding motility, invasion, and egress by connecting the micronemal adhesins with the actomyosin system. TgGAC binds to and stabilizes filamentous actin and specifically associates with the transmembrane adhesin TgMIC2. GAC localizes to the apical pole in invasive stages of \emph{Toxoplasma gondii} and \emph{Plasmodium berghei}, and apical positioning of TgGAC depends on an apical lysine methyltransferase, TgAKMT. GAC PH domain also binds to phosphatidic acid, a lipid mediator associated with microneme exocytosis. Collectively, these findings indicate a central role for GAC in spatially and temporally coordinating gliding motility and invasion.} } Damien Jacot, Nicolò Tosetti, Isa Pires, Jessica Stock, Arnault Graindorge, Yu-Fu Hung, Huijong Han, Rita Tewari, Inari Kursula, and Dominique Soldati-Favre, An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion, Cell Host Microbe 20, 731–743 (2016) ![[abstract]](/biblio/img/abstract.gif) [abstract]![[link]](/biblio/img/link.gif) doi:10.1016/j.chom.2016.10.020
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